PROTAC BRD4 Degrader-8

PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells.


Cat. No.: EX-A13717	Purity: >98%

	Chemical structure of PROTAC BRD4 Degrader-8

For research only, Do not use for Human!

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10mg	1650	check price and availability
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CAS No.	3026420-38-9
Purity	>98%
Formula	C53H61F2N9O11S2
Mol Weight	1102.232
Appearance	White to off-white solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, protect from light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
CoA	CoA of PROTAC BRD4 Degrader-8

Smiles:	O=C1C2=C3C(C=4C(N(CC3=CN2)C5=C(F)C=C(F)C=N5)=CC(C(NCCOCCOCCOCC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)[C@@](C)(C)C)=O)=O)=C(CS(C)(=O)=O)C4)=CN1C


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